Q: Please discuss if you saw a positive or negative effect of ACE inhibitor or ARB therapy.


This is a controversial topic. I was infected with COVID-19 in January 2020. To study this problem, I took 4 mg perindopril 5 days after the onset of the disease.  A few hours later, I continued to have high fever and a severe cough. Theoretically, COVID-19 invades the cells through ACE2, and some ACEI / ARB up-regulate ACE2, which may be beneficial to virus replication. Therefore, the consensus of cardiovascular experts in Hubei Province suggests that ACEI / ARB should be replaced with other antihypertensive drugs in the early stage of COVID-19.